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PRK14164 Protein Domain Family
PF16397: Domain of Unknown Function (DUF5171)
cobN Conserved Protein Domain Family
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PRK14164 Protein Domain Family - Product Description
PRK14164 is a conserved protein domain family identified within the Conserved Domain Database (CDD) of NCBI, specifically with PSSM ID: 237632. This particular family is associated with the heat shock protein GrpE and is currently classified as 'Provisional'. As a protein domain, it represents a distinct functional and structural unit within a larger protein, often indicative of specific biological roles or enzymatic activities. Its conservation across species suggests fundamental importance in biological processes, likely related to stress response given its association with heat shock proteins.
Pros
- This product provides a standardized classification for a conserved protein domain, aiding in genomic and proteomic research
- Its provisional status allows for ongoing refinement and integration of new scientific findings
- The association with GrpE, a heat shock protein, highlights its potential relevance in cellular stress response mechanisms.
Cons
- As a 'Provisional' classification, the full extent of its functional annotation and biological significance may still be under investigation
- It does not represent a commercially available product but rather a scientific classification, limiting direct revenue generation
- The information provided is highly specialized, catering primarily to bioinformatics and molecular biology researchers.
Alternatives
- Alternative protein domain classification systems include Pfam, InterPro, and SMART, each offering different scopes and annotation methods
- Researchers might also use direct sequence homology searches against general protein databases like UniProt or GenBank to identify similar domains
- For specific GrpE-related research, other heat shock protein families or chaperonins could be considered as functional alternatives in stress response pathways.
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